Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB)
signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …

The use of blood derivatives represents an alternative therapeutic approach that is gaining
interest in regenerative medicine due to its potential to stimulate and accelerate tissue …

Tissue injury may create a specific microenvironment for inducing the systemic participation
of stromal-like cells in the repair process. Here we show that substance P is an injury …

Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …

The insulin-like growth factor (IGF) family plays key roles in growth and development. In the
cornea, IGF family members have been implicated in proliferation, differentiation, and …

Bioactive peptides derived from proteins generally need to be folded into secondary
structures to activate downstream signaling pathways. However, synthetic peptides typically …

Low cell retention and engraftment after transplantation limit the successful application of
stem cell therapy for AKI. Engineered microenvironments consisting of a hydrogel matrix and …

Background/aims: Loss of corneal sensation results in the development of persistent corneal
epithelial defects. The combination of a substance P-derived peptide (FGLM-amide) and an …

Purpose: The purpose of this study was to evaluate the clinical outcome of patients with
refractory neurotrophic keratopathy (NK) in stages 2 and 3 treated with topical insulin …