The immune system in humans is a defense department against both exogenous and
endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological …

It is now apparent that immune mediators including complement, cytokines, and cells of the
innate and adaptive immune system contribute not only to blood pressure elevation but also …

Ovarian cancer has the highest mortality among gynecological malignancies, and exploring
effective strategies to reverse the immunosuppressive tumor microenvironment in patients …

Sepsis affects 25 million children per year globally, leading to 2.9 million deaths and
substantial disability in survivors. Extensive characterization of interactions between the host …

Rotavirus infection continues to be a significant public health problem in developing
countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines …

Memory CD8 T cells (Tmem) can be activated into innate-like killers by cytokines like IL-12,
IL-15, and/or IL-18; but mechanisms regulating this phenomenon (termed bystander …

T cell development is fundamental to immune system establishment, yet how this
development changes with age remains poorly understood. Here, we construct a …

Recent studies have shown that neonatal CD8+ T cells can undergo 'bystander activation'in
response to inflammatory cytokines and produce effector molecules such as IFNγ and …