All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

Enzymes have the potential to catalyse a wide variety of chemical reactions. They are
increasingly being sought as environmentally friendly and cost‐effective alternatives to …

Organic fluorine compounds have had a profound impact on the development of bioactives
for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals …

Thermostability enhancement is a fundamental aspect of protein engineering as a
biocatalyst's half-life is key for its industrial and biotechnological application, particularly at …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Natural enzymes have evolved to perform their cellular functions under complex selective
pressures, which often require their catalytic activities to be regulated by other proteins. We …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Linking cell signaling events to the fundamental physicochemical basis of the
conformational behavior of single molecules and ultimately to cellular function is a key …

Covering: 2000 to 2020 Natural products and their derivatives are commercially important
medicines, agrochemicals, flavors, fragrances, and food ingredients. Industrial strategies to …

Biocatalysis has emerged as a great addition to traditional chemical processes for
production of bulk chemicals and pharmaceuticals. To overcome the limitations of naturally …