Elucidation of the biology of stem cells of the lung parenchyma could revolutionise treatment
of patients with lung disorders such as cancer, acute respiratory distress syndrome …

Pulmonary fibrosis (PF) is characterized by inflammation and fibrosis of the interstitium and
destruction of alveolar histoarchitecture ultimately leading to a fatal impairment of lung …

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are
essential for the air–blood barrier function of lungs. AT1 cells have been shown to retain …

Branching morphogenesis in the lung serves as a model for the complex patterning that is
reiterated in multiple organs throughout development. β-catenin and Wnt signaling mediate …

Alveolar epithelial type I cells cover most of the internal surface area of the lungs.
Ultrastructural studies demonstrate that alveolar epithelial type I cell damage is frequently …

Type II epithelial cells are essential for lung development and remodeling, as they are
precursors for type I cells and can produce vascular mitogens. Although type II cell …

Although∼ 98% of the internal surface area of the lung is lined by alveolar type I cells, little
is known about the functions of this cell type. Using freshly isolated rat type I and type II cells …

Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are characterized by
excessive intraalveolar fibrin deposition, driven, at least in part by inflammation. The …

We used microarray analysis with Affymetrix rat chips to determine gene expression profiles
of freshly isolated rat type I (TI) and TII cells and cultured TII cells. Our goals were 1) to …

Abstract Thromboxane A2 (TXA2) is produced in the lungs of patients suffering from acute
lung injury (ALI). We assessed its contribution in disease progression using three different …