Molecular basis of human sperm capacitation
LC Puga Molina, GM Luque, PA Balestrini… - Frontiers in cell and …, 2018 - frontiersin.org
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …
[HTML][HTML] The dynamic plasticity of insulin production in β-cells
BB Boland, CJ Rhodes, JS Grimsby - Molecular metabolism, 2017 - Elsevier
Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …
to both acute and chronic changes in metabolic demand, persistently high demand for …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Calcium channels in the development, maturation, and function of spermatozoa
A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
[HTML][HTML] Central role of soluble adenylyl cyclase and cAMP in sperm physiology
MG Buffone, EV Wertheimer, PE Visconti… - Biochimica Et Biophysica …, 2014 - Elsevier
Abstract Cyclic adenosine 3′, 5′-monophosphate (cAMP), the first second messenger to
be described, plays a central role in cell signaling in a wide variety of cell types. Over the last …
be described, plays a central role in cell signaling in a wide variety of cell types. Over the last …
Multiple roles for the actin cytoskeleton during regulated exocytosis
Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …
Ca2+ signals generated by catsper and ca2+ stores regulate different behaviors in human sperm*[s]
W Alasmari, S Costello, J Correia, SK Oxenham… - Journal of Biological …, 2013 - ASBMB
Background: Ca 2+ signals, elicited by cues from the oocyte and female tract, regulate
human sperm behavior. Results: CatSper channel activation (flagellum) and Ca 2+ store …
human sperm behavior. Results: CatSper channel activation (flagellum) and Ca 2+ store …
Tetraspanins: host factors in viral infections
CS New, ZY Lee, KS Tan, AHP Wong… - International Journal of …, 2021 - mdpi.com
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as
host factors in infectious diseases. In particular, they were implicated in the pathogenesis of …
host factors in infectious diseases. In particular, they were implicated in the pathogenesis of …
Distinct initial SNARE configurations underlying the diversity of exocytosis
H Kasai, N Takahashi, H Tokumaru - Physiological reviews, 2012 - journals.physiology.org
The dynamics of exocytosis are diverse and have been optimized for the functions of
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …
Molecular mechanism for human sperm chemotaxis mediated by progesterone
Sperm chemotaxis is a chemical guiding mechanism that may orient spermatozoa to the egg
surface. A picomolar concentration gradient of Progesterone (P), the main steroidal …
surface. A picomolar concentration gradient of Progesterone (P), the main steroidal …