Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling
has enriched our understanding of cancer initiation and progression and has become …

The ALK gene encodes a transmembrane tyrosine kinase receptor. ALK is physiologically
expressed in the nervous system during embryogenesis, but its expression decreases …

Background Targeted therapies have transformed clinical management of advanced biliary
tract cancer (BTC). Cell-free DNA (cfDNA) analysis is an attractive approach for cancer …

Anaplastic lymphoma kinase (ALK) is a validated molecular target for non-small-cell lung
cancer (NSCLC). The use of tyrosine kinase inhibitors (TKIs) has led to significantly …

Since the discovery of echinoderm microtubule-associated protein-like 4 (EML4) and
anaplastic lymphoma kinase (ALK) gene fusion in non-small cell lung carcinoma (NSCLC) …

Since the discovery of anaplastic lymphoma kinase fusion-positive (ALK+) NSCLC in 2007,
the methods to detect ALK+ NSCLC have evolved and expanded from fluorescence in situ …

Anaplastic lymphoma kinase (ALK) can be driven to oncogenic activity by different types of
mutational events such as point‐mutations, for example F1174L in neuroblastoma, and …

In order to identify anaplastic lymphoma kinase‐driven non‐small cell lung cancer (ALK+
NSCLC) patients with a worse outcome, who might require alternative therapeutic …

Anaplastic lymphoma kinase-rearranged non-small-cell lung cancer (ALK+ NSCLC) is a
model disease for the use of targeted pharmaceuticals in thoracic oncology. Due to higher …