Tackling COVID-19 with neutralizing monoclonal antibodies
Monoclonal antibodies (mAbs) have revolutionized the treatment of several human
diseases, including cancer and autoimmunity and inflammatory conditions, and represent a …
diseases, including cancer and autoimmunity and inflammatory conditions, and represent a …
Antibodies to combat viral infections: development strategies and progress
G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
Efficient evolution of human antibodies from general protein language models
Natural evolution must explore a vast landscape of possible sequences for desirable yet
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
KW Ng, N Faulkner, GH Cornish, A Rosa, R Harvey… - Science, 2020 - science.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
Frequent outbreaks of coronaviruses underscore the need for antivirals and vaccines that
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
Quadrivalent influenza nanoparticle vaccines induce broad protection
S Boyoglu-Barnum, D Ellis, RA Gillespie… - Nature, 2021 - nature.com
Influenza vaccines that confer broad and durable protection against diverse viral strains
would have a major effect on global health, as they would lessen the need for annual …
would have a major effect on global health, as they would lessen the need for annual …
Learning the language of viral evolution and escape
The ability for viruses to mutate and evade the human immune system and cause infection,
called viral escape, remains an obstacle to antiviral and vaccine development …
called viral escape, remains an obstacle to antiviral and vaccine development …
The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
AL Cathcart, C Havenar-Daughton, FA Lempp, D Ma… - biorxiv, 2021 - biorxiv.org
ABSTRACT VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs)
targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS …
targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS …
Antiviral approaches against influenza virus
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …