Role of metabolic endotoxemia in systemic inflammation and potential interventions

S Mohammad, C Thiemermann - Frontiers in immunology, 2021 - frontiersin.org
Diet-induced metabolic endotoxemia is an important factor in the development of many
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …

Human intestinal barrier function in health and disease

J König, J Wells, PD Cani… - Clinical and …, 2016 - journals.lww.com
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently
absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a …

Obesity, inflammation, and the gut microbiota

AJ Cox, NP West, AW Cripps - The lancet Diabetes & endocrinology, 2015 - thelancet.com
As the prevalence of obesity and associated disease continues to rise and concerns for the
spiralling economic and social costs also escalate, innovative management strategies …

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

N Segata, SK Haake, P Mannon, KP Lemon, L Waldron… - Genome biology, 2012 - Springer
Background To understand the relationship between our bacterial microbiome and health, it
is essential to define the microbiome in the absence of disease. The digestive tract includes …

Metabolic endotoxemia with obesity: Is it real and is it relevant?

NE Boutagy, RP McMillan, MI Frisard, MW Hulver - Biochimie, 2016 - Elsevier
Obesity is associated with metabolic derangements in multiple tissues, which contribute to
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus …

Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

PD Cani, M Osto, L Geurts, A Everard - Gut microbes, 2012 - Taylor & Francis
Obesity is associated with metabolic alterations related to glucose homeostasis and
cardiovascular risk factors. These metabolic alterations are associated with low-grade …

Metabolic endotoxemia and diabetes mellitus: A systematic review

JMG Gomes, J de Assis Costa, RCG Alfenas - Metabolism, 2017 - Elsevier
In this systematic review we analyzed studies that assessed serum concentrations of
lipopolysaccharide (LPS) and/or lipopolysacharide-binding protein (LBP) in diabetic patients …

[HTML][HTML] Diabetes, obesity and gut microbiota

A Everard, PD Cani - Best practice & research Clinical gastroenterology, 2013 - Elsevier
The gut microbiota composition has been associated with several hallmarks of metabolic
syndrome (eg, obesity, type 2 diabetes, cardiovascular diseases, and non-alcoholic …

Gut microbiome, prebiotics, intestinal permeability and diabetes complications

M Snelson, C de Pasquale, EI Ekinci… - Best Practice & Research …, 2021 - Elsevier
Diabetes is a metabolic condition. The composition of the gut microbiota is altered in
diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate …

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

NM Delzenne, AM Neyrinck, F Bäckhed… - Nature Reviews …, 2011 - nature.com
At birth, the human colon is rapidly colonized by gut microbes. Owing to their vast number
and their capacity to ferment nutrients and secrete bioactive compounds, these …