Biomarkers predicting tissue pharmacokinetics of antimicrobials in sepsis: a review

M Sanz Codina, M Zeitlinger - Clinical Pharmacokinetics, 2022 - Springer
The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Fibrinogen-to-albumin ratio and blood urea nitrogen-to-albumin ratio in COVID-19 patients: a systematic review and meta-analysis

JR Ulloque-Badaracco, EA Alarcon-Braga… - Tropical Medicine and …, 2022 - mdpi.com
Fibrinogen-to-albumin ratio (FAR) and blood urea nitrogen-to-albumin ratio (BAR) are
inflammatory biomarkers that have been associated with clinical outcomes of multiple …

Elevated serum urea-to-creatinine ratio is associated with adverse inpatient clinical outcomes in non-end stage chronic kidney disease

EM Brookes, DA Power - Scientific reports, 2022 - nature.com
To better understand the role of the urea-to-creatinine ratio in chronic kidney disease
patients, we assessed the epidemiology of the urea-to-creatinine ratio among hospitalised …

Urine biochemistry assessment in the sequential evaluation of renal function: Time to think outside the box

AT Maciel, D Vitorio, EA Osawa - Frontiers in Medicine, 2022 - frontiersin.org
Urine biochemistry (UB) remains a controversial tool in acute kidney injury (AKI) monitoring,
being considered to be of limited value both in terms of AKI diagnosis and prognosis …

Effect of renal clearance on vancomycin area under the concentration–time curve deviations in critically ill patients

T Ishigo, Y Ibe, S Fujii, S Kazuma, T Aigami… - Journal of Infection and …, 2023 - Elsevier
Introduction Augmented renal clearance (ARC) increases vancomycin (VCM) clearance.
Therefore, higher VCM doses are recommended in patients with ARC; however, impacts of …

Urea to creatinine ratio as a predictor of persistent critical illness

L Statlender, T Shochat, E Robinson, G Fishman… - Journal of Critical …, 2024 - Elsevier
Introduction Persistent critical illness (PCI) is a syndrome in which the acute presenting
problem has been stabilized, but the patient's clinical state does not allow ICU discharge …

Simultaneous determination of multiple urine biomarkers for kidney injury using SPE combined with LC-MS/MS

H Sun, Q Li, Z Jin, Y Lu, Y Ju - Clinica Chimica Acta, 2024 - Elsevier
Abstract Background and Objectives Urinary biomarkers such as low molecular weight
proteins and small molecular weight metabolites are crucial in the diagnosis of kidney injury …

REDOX REDUX? glutamine, catabolism, and the urea-to-creatinine ratio as a novel nutritional metric

JS Kim, MJ Martin - Critical Care Medicine, 2022 - journals.lww.com
Chronic critical illness, persistent inflammation, and protein catabolism are unfortunately
common problems that continue to be seen in all ICUs or settings. Despite the advances in …

Analysis of patency rates and factors associated with arteriovenous fistula in maintenance hemodialysis patients followed for 10 years

P Liu, XT He, W Zhang, ZJ Fang - Renal Failure, 2023 - Taylor & Francis
Objective This study analyzed the long-term arteriovenous fistula (AVF) patency rate and its
determinants in patients undergoing maintenance hemodialysis. Methods General data and …

Clinical significance of serum urea‐to‐creatinine ratio in patients undergoing peritoneal dialysis

S Tonomura, K Uchiyama, T Nakayama… - Therapeutic …, 2023 - Wiley Online Library
Introduction We aimed to determine the correlation between the serum urea‐to‐creatinine
ratio and residual kidney function (RKF) in patients undergoing peritoneal dialysis (PD), as …