The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

In recent years, there have been many studies on the function of nitric oxide synthase (NOS)
in experimental animals and humans. This review analyzes and explores the relationship …

Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-
13, which can either be host protective or have pathogenic activity. Type 2 immunity …

The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …

Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The
majority of ovarian cancer patients suffer from relapse after standard of care therapies and …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

Neutrophils are the first responders to infection and injury and are critical for antimicrobial
host defense. Through the generation of reactive oxidants, activation of granular constituents …

Nitric oxide (NO) is a key messenger in the pathogenesis of inflammation, linking innate and
adaptive immunity. By targeting signaling molecules, NO from inducible NO synthase (iNOS) …