Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …

Background Persons with toxic gain-of-function variants in the gene encoding
apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive …

Background Studies have documented AKI with high-grade proteinuria in patients with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In some patients …

Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …

Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the
excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have …

The incidence and severity of sepsis is higher among individuals of African versus European
ancestry. We found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein …

Abstract Background People of Sub-Saharan African ancestry are at higher risk of
developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene …

Risk variants of the apolipoprotein-L1 (APOL1) gene are associated with severe kidney
disease, putting homozygous carriers at risk. Since APOL1 lacks orthologs in all major …

Coding variants (named G1 and G2) in Apolipoprotein L1 (APOL1) can explain most excess
risk of kidney disease observed in African American individuals. It has been proposed that …