Cardiovascular diseases remain an age-related pathology in both men and women. These
pathologies are 3-fold more frequent in men than in women before menopause, although …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating
liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised …

In healthy tissues, cells are in mechanical homeostasis. During cancer progression, this
equilibrium is disrupted. Cancer cells alter their mechanical phenotype to a softer and more …

The influence of biomechanics on cell function has become increasingly defined over recent
years. Biomechanical changes are known to affect oncogenesis; however, these effects are …

Congenital dyserythropoietic anemia type III (CDA III) is one of the rarest types of CDA. The
autosomal dominant form of CDA III, is due to mono-allelic mutations in the KIF23 gene …

The rho-associated coiled-coil-containing proteins (ROCKs or rho kinase) are effectors of
the small rho-GTPase rhoA, which acts as a signaling molecule to regulate a variety of …

Estrogen (17β-estradiol) deficiency post-menopause alters bone homeostasis whereby
bone resorption by osteoclasts exceeds bone formation by osteoblasts, leading to …

Context There is some evidence that an adequate “anabolic hormonal milieu” is essential for
the mechanosensitivity/transduction/response of bone tissue. Objective This work aimed to …

Understanding estrogen receptor (ER) signaling pathways is crucial for uncovering the
mechanisms behind estrogen-related diseases, such as breast cancer, and addressing the …