Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis
Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …
presence of pathology (eg, cancer), and it is these types of environments in which …
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction
J Pei, L Cai, F Wang, C Xu, S Pei, H Guo… - Circulation …, 2022 - Am Heart Assoc
Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular
events. Our previous study found that lysophosphatidic acid (LPA) is increased in human …
events. Our previous study found that lysophosphatidic acid (LPA) is increased in human …
LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis
Lysophosphatidic acid (LPA) is a potent lipid mediator with a wide variety of biological
actions mediated through G protein-coupled receptors (LPA1-6). LPA4 has been identified …
actions mediated through G protein-coupled receptors (LPA1-6). LPA4 has been identified …
Lymphatic/blood vessel plasticity: motivation for a future research area based on present and past observations
AO Lampejo, SAA Ghavimi… - American Journal …, 2023 - journals.physiology.org
The lymphatic system plays a significant role in homeostasis and drainage of excess fluid
back into venous circulation. Lymphatics are also associated with a number of diseases …
back into venous circulation. Lymphatics are also associated with a number of diseases …
Targeting the autotaxin–lysophosphatidic acid receptor axis in cardiovascular diseases
Y Zhao, S Hasse, C Zhao, SG Bourgoin - Biochemical pharmacology, 2019 - Elsevier
Lysophosphatidic acid (LPA) is a well-characterized bioactive lipid mediator, which is
involved in development, physiology, and pathological processes of the cardiovascular …
involved in development, physiology, and pathological processes of the cardiovascular …
G-protein-coupled lysophosphatidic acid receptors and their regulation of AKT signaling
A Riaz, Y Huang, S Johansson - International journal of molecular …, 2016 - mdpi.com
A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond
to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to …
to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to …
VEGF‐C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model
Objective Lymphatic and blood microvascular systems are critical for tissue function. Insights
into the coordination of both systems can be gained by investigating the relationships …
into the coordination of both systems can be gained by investigating the relationships …
Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of …
Endometriosis is an angiogenesis-dependent disease. Many studies demonstrated
inhibition of angiogenesis leads to inhibition of endometriotic growth, however underlying …
inhibition of angiogenesis leads to inhibition of endometriotic growth, however underlying …
Lysophosphatidic acid improves porcine oocyte maturation and embryo development in vitro
JY Zhang, Y Jiang, T Lin, JW Kang… - Molecular …, 2015 - Wiley Online Library
Lysophosphatidic acid (LPA), a member of the phospholipid autacoid family, is present in
human follicular fluid. The aim of the present study was to compare the developmental …
human follicular fluid. The aim of the present study was to compare the developmental …