Hippo signalling in the liver: role in development, regeneration and disease
JO Russell, FD Camargo - Nature reviews Gastroenterology & …, 2022 - nature.com
The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …
biology, such as development, cell fate determination, homeostatic function and …
Interplay between YAP/TAZ and Metabolism
JH Koo, KL Guan - Cell metabolism, 2018 - cell.com
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …
YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy
BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …
activated during the growth and progression of many solid tumors, including lung, colorectal …
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis
J Tong, X Lan, Z Zhang, Y Liu, D Sun, X Wang… - Acta Pharmacologica …, 2023 - nature.com
Ferroptosis is a new form of regulated cell death characterized by excessive iron
accumulation and uncontrollable lipid peroxidation. The role of ferroptosis in metabolic …
accumulation and uncontrollable lipid peroxidation. The role of ferroptosis in metabolic …
The Hippo pathway in liver homeostasis and pathophysiology
JH Driskill, D Pan - Annual review of pathology: mechanisms of …, 2021 - annualreviews.org
Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …
Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …
Advances in the diagnosis and treatment of non-alcoholic fatty liver disease
X Yin, X Guo, Z Liu, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that
affects approximately one-quarter of the global adult population, posing a significant threat …
affects approximately one-quarter of the global adult population, posing a significant threat …
The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription
A Xia, W Yuan, Q Wang, J Xu, Y Gu, L Zhang, C Chen… - Nature cancer, 2022 - nature.com
Cancer-testis (CT) genes participate in the initiation and progression of cancer, but the role
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) …
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) …
Integration of Hippo-YAP signaling with metabolism
The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …
integrator of signals that control cellular proliferation and differentiation. The past several …
mTOR: A potential new target in nonalcoholic fatty liver disease
J Feng, S Qiu, S Zhou, Y Tan, Y Bai, H Cao… - International journal of …, 2022 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …
effective treatments are lacking due to the complex pathogenesis of this disease. Although …