Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried
out by microglia, the resident myeloid cells of the brain. Here we show that microglia …

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that
exhibits extremely high levels of genetic complexity and yet a relatively uniform …

As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …

Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …

During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells
switch from oxidative to glycolytic metabolism, a transition associated with profound …

Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in
the establishment of somatic expression programs during embryonic stem cell (ESC) …