Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many
tissues and are known to actively migrate to sites of tissue injury, where they participate in …

Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …

Extracellular vesicles (EVs) secreted by cells present an attractive strategy for developing
new therapies, but progress in the field is limited by several issues: The quality of the EVs …

Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years,
however, acquired resistance has emerged as a daunting challenge to anticancer …

Breast cancer affects approximately 12% women worldwide and results in 14% of all cancer-
related fatalities. Breast cancer is commonly categorized into one of four main subtypes …

The interaction between tumor cells and non-malignant hosts cells within the tumor
microenvironment (TME) is critical to the pathophysiology of cancer. These non-malignant …

Metastasis is an inefficient process, especially during colonization at a distant organ. This
bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of …