Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by
cytokines and chemokines, can be distinguished according to their activation and cytokine …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …

Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

The development of an acidic tissue environment is a hallmark of a variety of inflammatory
processes and solid tumors. However, little attention has been paid so far to analyze the …

Neutrophils are the most abundant white blood cells in circulation, and patients with
congenital neutrophil deficiencies suffer from severe infections that are often fatal …

Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …

Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis.
Neutrophils can have a significant impact on the tumor microenvironment via their …

In recent years, the role of neutrophils in cancer biology has been a matter of increasing
interest. Many patients with advanced cancer show high levels of neutrophilia, tumor …