Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the
vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the …

Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular
understanding of their mechanism of action is still lacking. Here we summarize current …

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Antimicrobial peptides are an abundant and diverse group of molecules that are produced
by many tissues and cell types in a variety of invertebrate, plant and animal species. Their …

It is currently thought that immune responses are initiated by pathogen-associated molecular
patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups …

▪ Abstract Stably folded membrane proteins reside in a free energy minimum determined by
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …

Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

Defensins are peptidic components of the innate immune system of plants and animals. In
mammals, defensins have evolved to have a central function in the host defense properties …

Multidrug antibiotic resistance is an increasingly serious public health problem worldwide.
Thus, there is a significant and urgent need for the development of new classes of antibiotics …