Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Triple negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
which lacks oestrogen receptors, progesterone receptors and HER2 amplification, thereby …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Increasing evidence suggests that ion channels and pumps not only regulate membrane
potential, ion homeostasis, and electric signaling in excitable cells but also play important …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …