To understand complex biological systems requires the integration of experimental and
computational research—in other words a systems biology approach. Computational …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each
sequenced to a target depth of 15-fold coverage, to provide the research community with …

Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that
affects 210 million people in 76 countries. Here we present analysis of the 363 megabase …

Background Globodera pallida is a devastating pathogen of potato crops, making it one of
the most economically important plant parasitic nematodes. It is also an important model for …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

Neurons in Caenorhabditis elegans and other nematodes have been thought to lack
classical action potentials. Unexpectedly, we observe membrane potential spikes with …

The adoption of powerful software tools and computational methods from the software
industry by the scientific research community has resulted in a renewed interest in …

We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) in
Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation …

Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …