Perfluorooctane sulfonate (PFOS), an ubiquitous environmental pollutant, has been
associated with male reproductive disorders. However, the underlying mechanisms are not …

Significance: In recent decades, male fertility has been severely reduced worldwide. The
causes underlying this decline are multifactorial, and include, among others, genetic …

Male fertility relies on continual and robust spermatogenesis. Environmental hypoxia
adversely affects reproductive health in humans and animal studies provide compelling …

Human exposure to altitude is a model to study the role of oxygen in different areas of
physiology and pathophysiology. The aim of this study was to evaluate whether a short …

Many authors described negative but reversible effects of high-altitude hypoxic exposure on
animal and human fertility in terms of sperm concentration, function, and biochemical …

The distributions of species are not only determined by where they can survive–they must
also be able to reproduce. Although immigrant inviability is a well-established concept, the …

Background Tibetan pigs (TP) exhibit heritable adaptations to their hypoxic environments as
a result of natural selection. However, candidate proteins that affect the sperm quality of …

High altitude hypobaric hypoxia environment impairs male's reproductive function. Leptin is
an adipose tissue-derived hormone which regulates body weight homeostasis. Its receptor …

Background Intermittent hypobaric hypoxia (IHH) induces changes in the redox status and
structure in rat testis. These effects may be present in people at high altitudes, such as …

Deregulated expression of protein tyrosine phosphorylation has been implicated in testicular
response to different stimuli. Herein, YES1, a nonreceptor protein tyrosine kinase, was found …