A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells,
fibroblasts, immune cells, and among others, which work together to maintain optimal …

In the modern world, myocardial infarction is one of the most common cardiovascular
diseases, which are responsible for around 18 million deaths every year or almost 32% of all …

Oxidative stress plays a fundamental role in many conditions. Specifically, redox imbalance
inhibits endothelial cell (EC) growth, inducing cell death and senescence. We used global …

Heart failure (HF) is the terminal state of cardiovascular disease (CVD), leading numerous
patients to death every year. Cardiac tissue engineering is a multidisciplinary field of …

The discovery of induced pluripotent stem cells (iPSCs) and advancements in genome
editing technology introduced a new perspective to disease modeling as genetic factors can …

Background Pulmonary artery hypertension (PAH), which is characterized by an increase in
pulmonary circulation blood pressure, is a fatal disease, and its pathogenesis remains …

Due to the limited regenerative ability of cardiomyocytes, the disabling irreversible condition
of myocardial failure can only be treated with conservative and temporary therapeutic …

Abstract Background and Aims Fibrotic tissue formed after myocardial infarction (MI) can be
as detrimental as MI itself. However, current in vitro cardiac fibrosis models fail to …

Inborn errors of immunity (IEIs) unveil regulatory pathways of human immunity. We describe
a new IEI caused by mutations in the GTPase of the immune-associated protein 6 (GIMAP6) …

心脏毒性是导致药物研发失败和上市后撤市的原因之一. 然而, 目前的药物心脏毒性评价方法
存在临床相关性低, 重现性低, 处理量小等缺点. 建立准确可靠的方法评价药物的心脏毒性是当前 …