Method validation strategies involved in non-targeted metabolomics
Non-targeted metabolomics is the hypothesis generating, global unbiased analysis of all the
small-molecule metabolites present within a biological system, under a given set of …
small-molecule metabolites present within a biological system, under a given set of …
[HTML][HTML] Metabolome analysis for investigating host-gut microbiota interactions
Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases
have shown to have correlations with imbalanced microbiota, including obesity …
have shown to have correlations with imbalanced microbiota, including obesity …
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
Y Xiao, D Ma, YS Yang, F Yang, JH Ding, Y Gong… - Cell research, 2022 - nature.com
Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of
metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the …
metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the …
Deep learning accurately predicts estrogen receptor status in breast cancer metabolomics data
FM Alakwaa, K Chaudhary… - Journal of proteome …, 2018 - ACS Publications
Metabolomics holds the promise as a new technology to diagnose highly heterogeneous
diseases. Conventionally, metabolomics data analysis for diagnosis is done using various …
diseases. Conventionally, metabolomics data analysis for diagnosis is done using various …
The role of glutaminase in cancer
BK Masisi, R El Ansari, L Alfarsi, EA Rakha… - …, 2020 - Wiley Online Library
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised
as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with …
as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with …
A novel hybrid feature selection method considering feature interaction in neighborhood rough set
The interaction between features can provide essential information that affects the
performances of learning models. Nevertheless, most feature selection methods do not take …
performances of learning models. Nevertheless, most feature selection methods do not take …
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic
intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper …
intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper …
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with …
M Lampa, H Arlt, T He, B Ospina, J Reeves, B Zhang… - PloS one, 2017 - journals.plos.org
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to
utilize additional nutrient sources to meet their enhanced bioenergetic requirements …
utilize additional nutrient sources to meet their enhanced bioenergetic requirements …
Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery
Most cancers are lethal and metabolic alterations are considered a hallmark of this deadly
disease. Genomics and proteomics have contributed vastly to understand cancer biology …
disease. Genomics and proteomics have contributed vastly to understand cancer biology …
Crosstalk between estrogen signaling and breast cancer metabolism
E Kulkoyluoglu-Cotul, A Arca… - Trends in Endocrinology & …, 2019 - cell.com
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and
in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based …
in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based …