The properties of pyrimidine and pyrazine derivatives responsible for the existence of
antituberculosis activity are considered. Examples of synthesis and biological activity of the …

Pyrazinamide analogs 5a–h have been successfully synthesized by the Yamaguchi
esterification method with yields ranging from 6% to 86%. Among pyrazinamides 5a–h …

Molecular hybridization (MH) of heterocyclic rings has enabled scientists to design and
develop novel drugs and drug-like candidates. In our previous work, considering the …

Indole derivatives were synthetized based on the Fischer indole methodology using different
phenyl hydrazine hydrochlorides and either cyclohexanone or 2-butanone. The pre-and …

Pyrazine belongs to the 1, 4-diazines family, which is a significant class of heterocyclic
compounds. Various pyrazine derivatives have been produced and successfully confirmed …

Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and
morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen …

We report the design, synthesis, and in vitro antimicrobial activity of a series of N-substituted
3-aminopyrazine-2-carboxamides with free amino groups in position 3 on the pyrazine ring …

Modern agricultural cultivation relies heavily on genetically modified plants that survive after
exposure to herbicides that kill weeds. Despite this biotechnology, there is a growing need …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become a frequently
deadly infection due to increasing antimicrobial resistance. This serious issue has driven …

A series of substituted N-benzyl-3-chloropyrazine-2-carboxamides were prepared as
positional isomers of 5-chloro and 6-chloro derivatives, prepared previously. During the …