Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Cancer metabolism: phenotype, signaling and therapeutic targets

JH Park, WY Pyun, HW Park - Cells, 2020 - mdpi.com
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

M Sadrkhanloo, M Entezari, S Orouei, M Ghollasi… - Pharmacological …, 2022 - Elsevier
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of
tumor cells and their spread to various organs and tissues of body, providing undesirable …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

A Taheriazam, GGY Abad, S Hajimazdarany… - Journal of Controlled …, 2023 - Elsevier
Nanotechnology is a growing field, with many potential biomedical applications of
nanomedicine for the treatment of different diseases, particularly cancer, on the horizon …

Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: functions and therapeutic implication

CY Loh, A Arya, AF Naema, WF Wong, G Sethi… - Frontiers in …, 2019 - frontiersin.org
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Formononetin: a review of its anticancer potentials and mechanisms

KC Tay, LTH Tan, CK Chan, SL Hong… - Frontiers in …, 2019 - frontiersin.org
Cancer, a complex yet common disease, is caused by uncontrolled cell division and
abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for …