The halogen bond occurs when there is evidence of a net attractive interaction between an
electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic …

Supramolecular chemistry is “the chemistry of the intermolecular bond, covering the
structures and functions of the entities formed by association of two or more chemical …

In the field of noncovalent interactions a new paradigm has recently become popular. It
stems from the analysis of molecular electrostatic potentials and introduces a label, which …

Halogen bonding has been known in material science for decades, but until recently,
halogen bonds in protein–ligand interactions were largely the result of serendipitous …

Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that
are significantly more abundant than the other introns within polyadenylated transcripts; we …

Ring-opening transformations of donor–acceptor cyclopropanes (DAC) with carbon-
centered nucleophiles is a simple, straight-forward approach to 1, 3-bifunctional compounds …

Activated RAS GTPase signalling is a critical driver of oncogenic transformation and
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …

The concept of the halogen bond (or X‐bond) has become recognized as contributing
significantly to the specificity in recognition of a large class of halogenated compounds. The …

Halogen bond has attracted a great deal of attention in the past years for hit-to-lead-to-
candidate optimization aiming at improving drug-target binding affinity. In general, heavy …

Concomitant inhibition of multiple cancer-driving kinases is an established strategy to
improve the durability of clinical responses to targeted therapies. The difficulty of discovering …