Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …

[HTML][HTML] Proteus mirabilis biofilm: development and therapeutic strategies

R Wasfi, SM Hamed, MA Amer… - Frontiers in cellular and …, 2020 - frontiersin.org
Proteus mirabilis is a Gram negative bacterium that is a frequent cause of catheter-
associated urinary tract infections (CAUTIs). Its ability to cause such infections is mostly …

Biofilm lifestyle in recurrent urinary tract infections

ASA Lila, AAH Rajab, MH Abdallah, SMD Rizvi, A Moin… - Life, 2023 - mdpi.com
Urinary tract infections (UTIs) represent one of the most common infections that are
frequently encountered in health care facilities. One of the main mechanisms used by …

[HTML][HTML] Recent advances in design of new urease inhibitors: A review

P Kafarski, M Talma - Journal of advanced research, 2018 - Elsevier
Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi.
Bacterial enzyme is of special importance since it has been demonstrated as a potent …

[HTML][HTML] Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides

M Nakamoto, K Kunimura… - Experimental and …, 2020 - spandidos-publications.com
Allium plants, such as garlic, onion and leek have long been known to be effective in the
therapy of infectious diseases. In particular, garlic has a greater antimicrobial activity than …

Current insights into the mechanisms and management of infection stones

EJ Espinosa-Ortiz, BH Eisner, D Lange… - Nature Reviews …, 2019 - nature.com
Infection stones are complex aggregates of crystals amalgamated in an organic matrix that
are strictly associated with urinary tract infections. The management of patients who form …

[HTML][HTML] What's old is new again: Insights into diabetic foot microbiome

AAH Rajab, WAH Hegazy - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Diabetes is a chronic disease that is considered one of the most stubborn global health
problems that continues to defy the efforts of scientists and physicians. The prevalence of …

Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

D Zhang, RY Gan, JR Zhang, AK Farha… - … Reviews in Food …, 2020 - Wiley Online Library
In recent decades, reduced antimicrobial effectiveness, increased bacterial infection, and
newly emerged microbial resistance have become global public issues, leading to an urgent …

Assessment of the growth inhibition and anti-biofilm activity of aptamer (PmA2G02) against Proteus mirabilis 1429T

R Elumalai, A Vishwakarma, A Balakrishnan… - Research in …, 2024 - Elsevier
Proteus mirabilis is known to cause Catheter-associated urinary tract infections (CAUTIs),
which exhibit virulence factors linked to forming biofilms. Aptamers have recently been …

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …