Selective neuromodulation of the vagus nerve

A Fitchett, S Mastitskaya, K Aristovich - Frontiers in neuroscience, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an effective technique for the treatment of refractory
epilepsy and shows potential for the treatment of a range of other serious conditions …

Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives

M Cracchiolo, MM Ottaviani, A Panarese… - Journal of Neural …, 2021 - iopscience.iop.org
Bioelectronic medicine (BM) is an emerging new approach for developing novel
neuromodulation therapies for pathologies that have been previously treated with …

Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

Z Mridha, JW de Gee, Y Shi, R Alkashgari… - Nature …, 2021 - nature.com
Vagus nerve stimulation (VNS) is thought to affect neural activity by recruiting brain-wide
release of neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly …

[HTML][HTML] Quantitative estimation of nerve fiber engagement by vagus nerve stimulation using physiological markers

YC Chang, M Cracchiolo, U Ahmed, I Mughrabi… - Brain stimulation, 2020 - Elsevier
Background Cervical vagus nerve stimulation (VNS) is a rapidly emerging bioelectronic
treatment for brain, metabolic, cardiovascular and immune disorders. Its desired and off …

Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect

SL Blanz, ED Musselman, ML Settell… - Journal of neural …, 2023 - iopscience.iop.org
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-
approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …

Development and characterization of a chronic implant mouse model for vagus nerve stimulation

IT Mughrabi, J Hickman, N Jayaprakash, D Thompson… - Elife, 2021 - elifesciences.org
Vagus nerve stimulation (VNS) suppresses inflammation and autoimmune diseases in
preclinical and clinical studies. The underlying molecular, neurological, and anatomical …

Bioelectronic medicine: from preclinical studies on the inflammatory reflex to new approaches in disease diagnosis and treatment

VA Pavlov, SS Chavan… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Bioelectronic medicine is an evolving field in which new insights into the regulatory role of
the nervous system and new developments in bioelectronic technology result in novel …

Ultraflexible and stretchable intrafascicular peripheral nerve recording device with axon‐dimension, cuff‐less microneedle electrode array

D Yan, AA Jiman, EC Bottorff, PR Patel, D Meli… - Small, 2022 - Wiley Online Library
Peripheral nerve mapping tools with higher spatial resolution are needed to advance
systems neuroscience, and potentially provide a closed‐loop biomarker in neuromodulation …

Closed-loop vagus nerve stimulation for the treatment of cardiovascular diseases: state of the art and future directions

MM Ottaviani, F Vallone, S Micera… - Frontiers in …, 2022 - frontiersin.org
The autonomic nervous system exerts a fine beat-to-beat regulation of cardiovascular
functions and is consequently involved in the onset and progression of many cardiovascular …

Vagus nerve stimulation in rodent models: an overview of technical considerations

CM Noller, YA Levine, TM Urakov, JP Aronson… - Frontiers in …, 2019 - frontiersin.org
Over the last several decades, vagus nerve stimulation (VNS) has evolved from a treatment
for select neuropsychiatric disorders to one that holds promise in treating numerous …