Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside
mitochondria in which, together with the co-chaperonin Hsp10, maintains protein …

Although frank symptomatic biotin deficiency is rare, some evidence suggests that marginal
biotin deficiency occurs spontaneously in a substantial proportion of women during normal …

Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (1O2) and
superoxide radical (O2•–) is considered to trigger cell death pathways associated with …

Biotin is a water-soluble B-complex vitamin and is well-known as a co-factor for 5
indispensable carboxylases. Holocarboxylase synthetase (HLCS) catalyzes the biotinylation …

The essential vitamin biotin is a covalent and tenaciously attached prosthetic group in
several carboxylases that play important roles in the regulation of energy metabolism. Here …

Immune checkpoint blockade (ICB) has emerged as a promising therapeutic option for
hepatocellular carcinoma (HCC), but resistance to ICB occurs and patient responses vary …

Biotin is an essential cofactor for carboxylases that regulates the energy metabolism.
Recently, high‐dose pharmaceutical‐grade biotin (MD1003) was shown to improve clinical …

Determining which proteins are actively synthesized at a given point in time and extracting a
representative sample for analysis is important to understand plant responses. Here we …

CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids
and can activate natural killer T (NKT) cells through the presentation of lipid antigens. CD1d …

Biotin is a sulfur-containing water-soluble B-vitamin critical for human metabolism. Biotin
functions as a required cofactor for enzymes involved in carboxylation reactions essential for …