A long strand of DNA is wrapped around the core histone and forms a nucleosome.
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

Plants respond and adapt to drought, cold and high‐salinity stress in order to survive.
Molecular and genomic studies have revealed that many stress‐inducible genes with …

Emerging evidence is shedding light on a large and complex network of epigenetic
modifications at play in human stem cells. This “epigenetic landscape” governs the fine …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is
characterized by synovial hyperplasia and progressive joint destruction. The activation of RA …

Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix
(ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading …

Chromatin remodeling complexes (CRCs) use ATP hydrolysis to maintain correct
expression profiles, chromatin stability, and inherited epigenetic states. More than 20 CRCs …

Linker histone H1 is an important structural component of chromatin that stabilizes the
nucleosome and compacts the nucleofilament into higher-order structures. The biology of …

Histone tails play an important role in nucleosome structure and dynamics. Here we
investigate the effect of truncation of histone tails H3, H4, H2A and H2B on nucleosome …