Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …

The importance of histone variant H2A. Z in transcription regulation has been well
established, yet its mechanism-of-action remains enigmatic. Conflicting evidence exists in …

Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …

CENP-A is an essential histone variant that replaces the canonical H3 at the centromeres
and marks these regions epigenetically. The CENP-A nucleosome is the specific building …

Multiple testis-specific histone variants are involved in the dynamic chromatin transitions
during spermatogenesis. H2B. W1 (previously called H2BFWT) is an H2B variant specific to …

Considerable progress has been made recently in defining the interactions of linker histones
(H1s) within nucleosomes. Major advancements include atomic resolution structures of the …