Marine natural products

JW Blunt, BR Copp, RA Keyzers, MHG Munro… - Natural product …, 2014 - pubs.rsc.org
Covering: 2012. Previous review: Nat. Prod. Rep., 2013, 30, 237–323. This review covers
the literature published in 2012 for marine natural products, with 1035 citations (673 for the …

Marine pharmacology in 2012–2013: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral …

AMS Mayer, AD Rodríguez, O Taglialatela-Scafati… - Marine drugs, 2017 - mdpi.com
The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically
reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology …

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

JD Osteen, V Herzig, J Gilchrist, JJ Emrick, C Zhang… - Nature, 2016 - nature.com
Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non …

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1. 6 in peripheral pain pathways

JR Deuis, K Zimmermann, AA Romanovsky… - Pain®, 2013 - Elsevier
Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin
infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory …

Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential

ZH Chen, YW Guo, XW Li - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2021 Marine mollusks, which are well known as rich sources of diverse and
biologically active natural products, have attracted significant attention from researchers due …

Sodium channels and pain: From toxins to therapies

FC Cardoso, RJ Lewis - British journal of pharmacology, 2018 - Wiley Online Library
Voltage‐gated sodium channels (NaV channels) are essential for the initiation and
propagation of action potentials that critically influence our ability to respond to a diverse …

Therapeutic potential of cone snail venom peptides (conopeptides)

I Vetter, RJ Lewis - Current topics in medicinal chemistry, 2012 - ingentaconnect.com
Cone snails have evolved many 1000s of small, structurally stable venom peptides
(conopeptides) for prey capture and defense. Whilst< 0.1% have been pharmacologically …

Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks

V Lavergne, I Harliwong, A Jones… - Proceedings of the …, 2015 - National Acad Sciences
Cone snails are predatory marine gastropods characterized by a sophisticated venom
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …

Diaminodiacid bridges to improve folding and tune the bioactivity of disulfide‐rich peptides

Y Guo, DM Sun, FL Wang, Y He, L Liu… - Angewandte Chemie …, 2015 - Wiley Online Library
Disulfide‐rich peptides containing three or more disulfide bonds are promising therapeutic
and diagnostic agents, but their preparation is often limited by the tedious and low‐yielding …

The snake with the scorpion's sting: Novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

DC Yang, JR Deuis, D Dashevsky, J Dobson… - Toxins, 2016 - mdpi.com
Millions of years of evolution have fine-tuned the ability of venom peptides to rapidly
incapacitate both prey and potential predators. Toxicofera reptiles are characterized by …