1. INTRODUCTION Heme proteins are among the most versatile players in the biological
milieu; their functions range widely and include electron transfer, catalysis, and small …

Inborn errors of metabolism (IEM) comprise a large class of recessive genetic diseases
involving disorders of cellular metabolism that tend to be caused by missense mutations in …

Enzymes that bear a nonnative or artificially introduced metal center can engender novel
reactivity and enable new spectroscopic and structural studies. In the case of metal-organic …

Heme-based gas sensors are an emerging class of heme proteins. Af GcHK, a globin-
coupled histidine kinase from Anaeromyxobacter sp. Fw109-5, is an oxygen sensor enzyme …

Mononuclear non-heme iron complexes that serve as structural and functional mimics of the
thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase …

Cysteine dioxygenase (CDO) is a mononuclear nonheme iron (II)-dependent enzyme critical
for maintaining appropriate cysteine (Cys) and taurine levels in eukaryotic systems. Because …

CBSs (cystathionine β-synthases) are eukaryotic PLP (pyridoxal 5*-phosphate)-dependent
proteins that maintain cellular homocysteine homoeostasis and produce cystathionine and …

Cystathionine β-synthase (CBS) is an essential pyridoxal 5′-phosphate (PLP)-dependent
enzyme of the transsulfuration pathway that condenses serine with homocysteine to form …

Cobalt is a trace transition metal. Although it is not abundant on earth, tens of cobalt‐
containing proteins exist in life. Moreover, the characteristic spectrum of Co (II) ion makes it a …

Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in
the processing machinery play a key role in many human diseases. In 22q11. 2 deletion …