ac4C RNA modification in Cancer: Unraveling Multifaceted Roles and Promising Therapeutic Horizons
W Ouyang, Z Huang, K Wan, T Nie, H Chen, H Yao - Cancer Letters, 2024 - Elsevier
RNA modifications play a crucial role in cancer development, profoundly influencing various
stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export …
stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export …
[HTML][HTML] Machine learning applications in RNA modification sites prediction
Ribonucleic acid (RNA) modifications are post-transcriptional chemical composition
changes that have a fundamental role in regulating the main aspect of RNA function …
changes that have a fundamental role in regulating the main aspect of RNA function …
iRNA-ac4C: a novel computational method for effectively detecting N4-acetylcytidine sites in human mRNA
W Su, XQ Xie, XW Liu, D Gao, CY Ma, H Zulfiqar… - International Journal of …, 2023 - Elsevier
Abstract RNA N4-acetylcytidine (ac4C) is the acetylation of cytidine at the nitrogen-4
position, which is a highly conserved RNA modification and involves a variety of biological …
position, which is a highly conserved RNA modification and involves a variety of biological …
Attention-based graph neural network for molecular solubility prediction
Drug discovery (DD) research is aimed at the discovery of new medications. Solubility is an
important physicochemical property in drug development. Active pharmaceutical ingredients …
important physicochemical property in drug development. Active pharmaceutical ingredients …
LSA-ac4C: a hybrid neural network incorporating double-layer LSTM and self-attention mechanism for the prediction of N4-acetylcytidine sites in human mRNA
FL Lai, F Gao - International Journal of Biological Macromolecules, 2023 - Elsevier
Abstract N4-acetylcytidine (ac4C) is a vital constituent of the epitranscriptome and plays a
crucial role in the regulation of mRNA expression. Numerous studies have established …
crucial role in the regulation of mRNA expression. Numerous studies have established …
DeepAc4C: a convolutional neural network model with hybrid features composed of physicochemical patterns and distributed representation information for …
Abstract Motivation N4-acetylcytidine (ac4C) is the only acetylation modification that has
been characterized in eukaryotic RNA, and is correlated with various human diseases …
been characterized in eukaryotic RNA, and is correlated with various human diseases …
DeepCap-Kcr: accurate identification and investigation of protein lysine crotonylation sites based on capsule network
Lysine crotonylation (Kcr) is a posttranslational modification widely detected in histone and
nonhistone proteins. It plays a vital role in human disease progression and various cellular …
nonhistone proteins. It plays a vital role in human disease progression and various cellular …
Weakly supervised learning of RNA modifications from low-resolution epitranscriptome data
Motivation Increasing evidence suggests that post-transcriptional ribonucleic acid (RNA)
modifications regulate essential biomolecular functions and are related to the pathogenesis …
modifications regulate essential biomolecular functions and are related to the pathogenesis …
Recognition of mRNA N4 acetylcytidine (ac4C) by using non-deep vs. Deep learning
Deep learning models have been successfully applied in a wide range of fields. The
creation of a deep learning framework for analyzing high-performance sequence data have …
creation of a deep learning framework for analyzing high-performance sequence data have …
EMDL-ac4C: identifying N4-acetylcytidine based on ensemble two-branch residual connection DenseNet and attention
J Jia, Z Wei, X Cao - Frontiers in Genetics, 2023 - frontiersin.org
Introduction: N4-acetylcytidine (ac4C) is a critical acetylation modification that has an
essential function in protein translation and is associated with a number of human diseases …
essential function in protein translation and is associated with a number of human diseases …