NETosis: molecular mechanisms, role in physiology and pathology

NV Vorobjeva, BV Chernyak - Biochemistry (Moscow), 2020 - Springer
NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …

[HTML][HTML] Understanding the role of neutrophils in acute respiratory distress syndrome

SC Yang, YF Tsai, YL Pan, TL Hwang - Biomedical Journal, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high
mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to …

[HTML][HTML] Nanomedicine for acute respiratory distress syndrome: the latest application, targeting strategy, and rational design

Q Qiao, X Liu, T Yang, K Cui, L Kong, C Yang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation
and destruction of the lung air–blood barrier, leading to irreversible and substantial …

Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

K Wang, M Wang, X Liao, S Gao, J Hua, X Wu… - Nature …, 2022 - nature.com
Acute respiratory distress syndrome (ARDS) is a common respiratory critical syndrome with
no effective therapeutic intervention. Neutrophils function in the overwhelming inflammatory …

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

P Mehta, JC Porter, JJ Manson, JD Isaacs… - The Lancet …, 2020 - thelancet.com
The COVID-19 pandemic is a global public health crisis, with considerable mortality and
morbidity exerting pressure on health-care resources, including critical care. An excessive …

Inflammatory caspases drive pyroptosis in acute lung injury

B Liu, R He, L Zhang, B Hao, W Jiang… - Frontiers in …, 2021 - frontiersin.org
Acute lung injury (ALI), a critical respiratory disorder that causes diffuse alveolar injury leads
to high mortality rates with no effective treatment. ALI is characterized by varying degrees of …

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia

WG Land - Genes & Immunity, 2021 - nature.com
When surveying the current literature on COVID-19, the “cytokine storm” is considered to be
pathogenetically involved in its severe outcomes such as acute respiratory distress …

The impact of hypoxia on neutrophil degranulation and consequences for the host

KM Lodge, AS Cowburn, W Li, AM Condliffe - International journal of …, 2020 - mdpi.com
Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host
against invading pathogens. Neutrophils may kill pathogens intracellularly, following …

Apoptotic neutrophil-mediated inflammatory microenvironment regulation for the treatment of ARDS

X Liu, Q Qiao, X Li, X Ou, K Cui, B Niu, C Yang, L Kong… - Nano Today, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a critical respiratory disease characterized by
uncontrolled acute lung inflammation with high mortality. At present, effective therapeutic …

Innate immune deficiencies are associated with severity and poor prognosis in patients with COVID-19

M Peyneau, V Granger, PH Wicky, D Khelifi-Touhami… - Scientific reports, 2022 - nature.com
COVID-19 can cause acute respiratory distress syndrome, leading to death in many
individuals. Evidence of a deleterious role of the innate immune system is accumulating, but …