Bioinformatics pipelines are essential in the analysis of genomic and transcriptomic data
generated by next-generation sequencing (NGS). Recent guidelines emphasize the need …

Publicly available gene expression datasets deposited in the Gene Expression Omnibus
(GEO) are growing at an accelerating rate. Such datasets hold great value for knowledge …

Abstract Summary The Gene Expression Omnibus (GEO) database provides an invaluable
resource of publicly available gene expression data that can be integrated and analyzed to …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CFTR gene. Although
viral respiratory tract infections are, in general, more severe in patients with CF compared …

Chronic Pseudomonas aeruginosa lung infections are a feature of cystic fibrosis (CF) that
many patients experience even with the advent of highly effective modulator therapies …

Developing software tools that leverage biological data sets to accelerate drug discovery is
an important aspect of bioinformatic research. Here, we present a novel example: a web …

Abstract Motivation Gene Expression Omnibus (GEO) and other publicly available data store
their metadata in the format of unstructured English text, which is very difficult for automated …

Interleukin‐18 (IL‐18) belongs to the IL‐1 family and is an essential proinflammatory and
immune regulatory cytokine. The present study was designed to investigate the expression …

In the next-generation sequencing era, RT-qPCR is still widely employed to quantify levels
of nucleic acids of interest due to its popularity, versatility, and limited costs. The …

Background Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for SARS-
CoV-2. It plays critical roles in both the transmission and the pathogenesis of COVID-19 …