Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …

We report here the identification of a ligand-receptor system that, upon engagement, leads
to the establishment of an antiviral state. Three closely positioned genes on human …

Expression of IL-22 is induced in several human inflammatory conditions, including
inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate …

Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell
populations. Its main biological function seems to be the limitation and termination of …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

The central role of T cell activation in hepatocellular injury has been well documented. In this
article, we provide evidence suggesting that T cells may also play a protective role in liver …

IL (interleukin)-22 is an IL-10-related cytokine; its main biological activity known thus far is
the induction of acute phase reactants in liver and pancreas. IL-22 signals through a …

Large DNA viruses defend against hostile assault executed by the host immune system by
producing an array of gene products that systematically sabotage key components of the …

In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped
into the so-called IL-10 family of cytokines based on their similarities with respect to the …