Microneedle array systems for long-acting drug delivery

LK Vora, K Moffatt, IA Tekko, AJ Paredes… - European Journal of …, 2021 - Elsevier
The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis

AD Permana, AJ Paredes, FV Zanutto… - … Applied Materials & …, 2021 - ACS Publications
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both
humans and animals' lives. Current treatment of CE by oral administration of albendazole …

Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

AJ Paredes, F Volpe-Zanutto, AD Permana… - International journal of …, 2021 - Elsevier
Finasteride (FND) is a competitive inhibitor of 5α-reductase, an enzyme involved in benign
prostatic hyperplasia (BPH) and androgenic alopecia. FND is administered in oral, often …

Microarray patches: poking a hole in the challenges faced when delivering poorly soluble drugs

AJ Paredes, PE McKenna, IK Ramöller… - Advanced Functional …, 2021 - Wiley Online Library
Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …

Microarray patches: breaking down the barriers to contraceptive care and HIV prevention for women across the globe

AJ Paredes, IK Ramöller, PE McKenna… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the existence of a variety of contraceptive products for women, as well as decades
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …

Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Y Wu, LK Vora, D Mishra, MF Adrianto, S Gade… - Biomaterials …, 2022 - Elsevier
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

CJ Picco, J Domínguez-Robles, E Utomo… - Drug Delivery, 2022 - Taylor & Francis
Implantable drug delivery systems offer an alternative for the treatments of long-term
conditions (ie schizophrenia, HIV, or Parkinson's disease among many others). The …

[HTML][HTML] Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

MB Bianchi, C Zhang, E Catlin, G Sandri, M Calderón… - Materials Today Bio, 2022 - Elsevier
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional
temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non …

Polymeric microarray patches for enhanced transdermal delivery of the poorly soluble drug olanzapine

PE McKenna, MTA Abbate, LK Vora… - … Applied Materials & …, 2023 - ACS Publications
Transdermal drug delivery is an alternative route of administration that offers avoidance of
the associated drawbacks of orally and parenterally administered hydrophobics. However …