Microneedle array systems for long-acting drug delivery
The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …
highly active for more than two decades. The minimally invasive and self-administered MN …
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride
Finasteride (FND) is a competitive inhibitor of 5α-reductase, an enzyme involved in benign
prostatic hyperplasia (BPH) and androgenic alopecia. FND is administered in oral, often …
prostatic hyperplasia (BPH) and androgenic alopecia. FND is administered in oral, often …
Microarray patches: poking a hole in the challenges faced when delivering poorly soluble drugs
AJ Paredes, PE McKenna, IK Ramöller… - Advanced Functional …, 2021 - Wiley Online Library
Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …
Microarray patches: breaking down the barriers to contraceptive care and HIV prevention for women across the globe
AJ Paredes, IK Ramöller, PE McKenna… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the existence of a variety of contraceptive products for women, as well as decades
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …
Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs
CJ Picco, J Domínguez-Robles, E Utomo… - Drug Delivery, 2022 - Taylor & Francis
Implantable drug delivery systems offer an alternative for the treatments of long-term
conditions (ie schizophrenia, HIV, or Parkinson's disease among many others). The …
conditions (ie schizophrenia, HIV, or Parkinson's disease among many others). The …
[HTML][HTML] Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
MB Bianchi, C Zhang, E Catlin, G Sandri, M Calderón… - Materials Today Bio, 2022 - Elsevier
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional
temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non …
temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non …
Polymeric microarray patches for enhanced transdermal delivery of the poorly soluble drug olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of
the associated drawbacks of orally and parenterally administered hydrophobics. However …
the associated drawbacks of orally and parenterally administered hydrophobics. However …