The facts that many proteins with crucial biological functions do not have unique structures
and that many biological processes are compartmentalized into the liquid-like biomolecular …

Evolutionary preservation of protein structure had a major influence on the field of molecular
evolution: changes in individual amino acids that did not disrupt protein folding would either …

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-
function relationship in these regions is poorly understood, in part because the primary …

Although RNA-binding proteins (RBPs) are known to be enriched in intrinsic disorder, no
previous analysis focused on RBPs interacting with specific RNA types. We fill this gap with …

Understanding the dynamics of species adaptation to their environments has long been a
central focus of the study of evolution. Theories of adaptation propose that populations …

All proteomes contain both proteins and polypeptide segments that don't form a defined
three-dimensional structure yet are biologically active—called intrinsically disordered …

Several mammalian genes have originated from the domestication of retrotransposons,
selfish mobile elements related to retroviruses. Some of the proteins encoded by these …

The acidic activation domain (AD) of yeast transcription factor Gal4 plays a dual role in
transcription repression and activation through binding to Gal80 repressor and Mediator …

Orthopoxviruses comprise several relevant pathogens, including the causative agent of
smallpox and monkeypox virus. Analysis of orthopoxvirus genome evolution mainly focused …

A hallmark of biological systems is that particular functions and outcomes are realized in
specific contexts, such as when particular signals are received. One mechanism for …