Epigenetic control of CD8+ T cell differentiation
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
Tolerance and exhaustion: defining mechanisms of T cell dysfunction
A Schietinger, PD Greenberg - Trends in immunology, 2014 - cell.com
CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
Chromatin states define tumour-specific T cell dysfunction and reprogramming
M Philip, L Fairchild, L Sun, EL Horste, S Camara… - Nature, 2017 - nature.com
Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability …
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability …
SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
CA Cohen, APY Li, A Hachim, DSC Hui… - Nature …, 2021 - nature.com
SARS-CoV-2 infection of children leads to a mild illness and the immunological differences
with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected …
with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected …
Transcriptional and epigenetic regulation of effector and memory CD8 T cell differentiation
Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …
Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8+ T cell differentiation
The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …
Glycolysis and oxidative phosphorylation play critical roles in natural killer cell receptor-mediated natural killer cell functions
Natural killer (NK) cells are innate lymphocytes that directly kill tumor and pathogen-infected
cells upon activation by cytokines and NK cell receptors (NKRs) without previous …
cells upon activation by cytokines and NK cell receptors (NKRs) without previous …
Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion
T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before
becoming functionally and phenotypically “exhausted” in settings of chronic infection …
becoming functionally and phenotypically “exhausted” in settings of chronic infection …
Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis
Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T
cell–mediated immunity. In this study, we report that maintenance of human memory CD8 T …
cell–mediated immunity. In this study, we report that maintenance of human memory CD8 T …
TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection
H Wang, H Luo, X Wan, X Fu, Q Mao, X Xiang… - Journal of …, 2020 - Elsevier
Background & Aims The role of hepatitis B virus (HBV)-specific CD4 T cells in patients with
chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic …
chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic …