During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment available. An increasing number of genetic causes of ALS are being identified, but …

The developing nervous system is a complex yet organized system of neurons, glial support
cells, and extracellular matrix that arranges into an elegant, highly structured network. The …

Although originally discovered as neuronal growth cone-collapsing factors, repulsive
guidance molecules (RGMs) are now known as key players in many fundamental …

Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of
nervous system development and plasticity, ranging from axon guidance and neuron …

During cell migration or differentiation, cell surface receptors are simultaneously exposed to
different ligands. However, it is often unclear how these extracellular signals are integrated …

Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains
unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability …