Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
G Pearson, F Robinson, T Beers Gibson, B Xu… - Endocrine …, 2001 - academic.oup.com
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …
protein-serine/threonine kinases, which participate in signal transduction pathways that …
The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions
Y Keshet, R Seger - MAP Kinase Signaling Protocols: Second Edition, 2010 - Springer
Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …
MAP kinases
Z Chen, TB Gibson, F Robinson, L Silvestro… - Chemical …, 2001 - ACS Publications
MAP Kinases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …
Reactive oxygen species-induced activation of the MAP kinase signaling pathways
JA McCubrey, MM LaHair… - Antioxidants & redox …, 2006 - liebertpub.com
An abundance of scientific literature exists demonstrating that oxidative stress influences the
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis
Although IL-17 is emerging as an important cytokine in cancer promotion and progression,
the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 …
the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 …
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
B Xu, JM English, JL Wilsbacher, S Stippec… - Journal of Biological …, 2000 - ASBMB
We have cloned and characterized a novel mammalian serine/threonine protein kinase
WNK1 (withno lysine (K)) from a rat brain cDNA library. WNK1 has 2126 amino acids and …
WNK1 (withno lysine (K)) from a rat brain cDNA library. WNK1 has 2126 amino acids and …
MEK and the inhibitors: from bench to bedside
A Akinleye, M Furqan, N Mukhi, P Ravella… - Journal of hematology & …, 2013 - Springer
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been
identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK …
identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK …
SELECTIVITY IN NEUROTROPHIN SIGNALING: Theme and Variations
RA Segal - Annual review of neuroscience, 2003 - annualreviews.org
▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …
functioning of the nervous system. Although originally identified as neuronal survival factors …
Mapk signalling: Erk5 versus erk1/2
S Nishimoto, E Nishida - EMBO reports, 2006 - embopress.org
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
Transcriptional regulation by the MAP kinase signaling cascades
SH Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2003 - Elsevier
A major function of the mitogen-activated protein kinase (MAPK) pathways is to control
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …