Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Nanoparticle-based mRNA therapeutics hold great promise, but cellular internalization and
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

Single-cell RNA sequencing has revolutionized our understanding of cellular heterogeneity,
but routine methods require cell lysis and fail to probe the dynamic trajectories responsible …

Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably
in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond …

Chimeric receptor T cells (CAR-T) can effectively cure leukemia; however, there are two
limitations: a complicated preparation process ex vivo and cytokine release syndrome …

Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Chimeric antigen receptor T cell (CAR T cell) therapy is a revolutionary approach approved
by the FDA and EMA to treat B cell malignancies and multiple myeloma. The production of …