BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …

Summary The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …

The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …

The establishment of DNA methylation patterns requires de novo methylation that occurs
predominantly during early development and gametogenesis in mice. Here we demonstrate …

Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA
methyltransferase gene. ES cell lines homozygous for the mutation were generated by …

Epigenetic signals are responsible for the establishment, maintenance, and reversal of
metastable transcriptional states that are fundamental for the cell's ability to “remember” past …

It has been suggested that cancer represents an alteration in DNA, heritable by progeny
cells, that leads to abnormally regulated expression of normal cellular genes; DNA …

▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …