Machine perfusion in liver transplantation

RX Sousa Da Silva, A Weber, P Dutkowski… - …, 2022 - Wiley Online Library
Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

[HTML][HTML] Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?

B Lascaris, VE de Meijer, RJ Porte - Journal of Hepatology, 2022 - Elsevier
Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

Transplantation of a human liver following 3 days of ex situ normothermic preservation

PA Clavien, P Dutkowski, M Mueller… - Nature …, 2022 - nature.com
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …

Long-term ex situ normothermic perfusion of human split livers for more than 1 week

NS Lau, M Ly, C Dennis, A Jacques… - Nature …, 2023 - nature.com
Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …

Machine perfusion of the liver and bioengineering

A Schlegel, H Mergental, C Fondevila, RJ Porte… - Journal of …, 2023 - Elsevier
With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Long‐term normothermic perfusion of human livers for longer than 12 days

NS Lau, M Ly, C Dennis, K Liu, J Kench… - Artificial …, 2022 - Wiley Online Library
Ex situ machine perfusion technology has provided the opportunity for assessment and
resuscitation of grafts prior to implant but the focus of this technology has so far been on …

Defatting of human livers during long-term ex situ normothermic perfusion: novel strategy to rescue discarded organs for transplantation

RXS Da Silva, LB Borrego, D Lenggenhager… - Annals of …, 2023 - journals.lww.com
Objective: To develop a protocol for the defatting of steatotic liver grafts during long-term ex
situ normothermic machine perfusion. Background: Despite the alarming increase in donor …

Abdominal organ preservation solutions in the age of machine perfusion

P Ramos, P Williams, J Salinas, J Vengohechea… - …, 2023 - journals.lww.com
The past decade has been the foreground for a radical revolution in the field of preservation
in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage …

Sex disparities in outcomes following major liver surgery: new powers of estrogen?

DL Birrer, M Linecker, V López-López… - Annals of …, 2022 - journals.lww.com
Aim: To explore potential sex differences in outcomes and regenerative parameters post
major hepatectomies. Background: Although controversial, sex differences in liver …

Postoperative length of stay following kidney transplantation in patients without delayed graft function—An analysis of center‐level variation and patient outcomes

SS Bakhtiyar, S Sakowitz, A Verma… - Clinical …, 2023 - Wiley Online Library
Background Early discharge after surgical procedures has been proposed as a novel
strategy to reduce healthcare expenditures. However, national analyses of the association …