The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related
to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For …

Obesity is the result of energy intake chronically exceeding energy expenditure. Classical
treatments against obesity do not provide a satisfactory long‐term outcome for the majority of …

Obesity is a pandemic disease associated with many metabolic alterations and involves
several organs and systems. The endocannabinoid system (ECS) appears to be a key …

De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white
adipose tissue (WAT); however, what regulates this process remains unclear. Here, we …

Adipose tissue is traditionally categorized into white and brown relating to their function and
morphology. The classical white adipose tissue builds up energy in the form of triglycerides …

Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting
inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis …

Renal ischemia reperfusion injury (IRI) is a leading and common cause of acute kidney
injury (AKI), and inflammation is a critical factor in ischemic AKI progression. Calycosin …

An important measure of cardiovascular health is obtained by evaluating the global
cardiovascular risk, which comprises a number of factors, including hypertension and type 2 …

Obesity and insulin resistance are two major risk factors for the development of metabolic
syndrome, type 2 diabetes and associated cardiovascular diseases (CVDs) …