The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and
regulate gene expression within the nucleus. Evidence collected mainly from the peripheral …

Extracellular histones are crucial damage-associated molecular patterns involved in the
development and progression of multiple critical and inflammatory diseases, such as sepsis …

Despite advances in medical treatments for severe trauma, it remains a critical condition
associated with high mortality. During trauma, the release of endogenous damage …

Leveraging the understanding of extracellular histone neutralization will pave the way for
development of novel pharmacological interventions to treat and prevent complications …

ABSTRACT Human immunodeficiency virus 1 (HIV-1) infection remains a global health
concern, with nearly 30 million people on antiretroviral (ARV) treatment. Integrase strand …

In short-term diabetes (3 weeks), suramin, a drug used clinically, affects renal function and
the expression of vascular endothelial growth factor A (VEGF-A), which may be involved in …

Background The association between neutrophil extracellular traps (NETs) and the
requirement for vasopressor and inotropic support in vasoplegic shock is unclear. This study …

Objective Vascular endothelial cells (ECs) sense and respond to both trauma factors
(histone proteins) and sepsis signals (bacterial lipopolysaccharide, LPS) with elevations in …