One health implications of fur farming

C Warwick, A Pilny, C Steedman… - Frontiers in Animal Science, 2023 - frontiersin.org
Fur farming involves the captive-breeding, rearing, and killing of between 85–100 million
animals annually for their pelts. The purpose of this report is to summarise key areas of …

Computational methods in the analysis of SARS-CoV-2 in mammals: A systematic review of the literature

PV Silva, CN Nobre - Computers in Biology and Medicine, 2024 - Elsevier
SARS-CoV-2 is an enveloped RNA virus that causes severe respiratory illness in humans
and animals. It infects cells by binding the Spike protein to the host's angiotensin-converting …

Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease

M Rajendran, MC Ferran, L Mouli, GA Babbitt… - Biophysical Reports, 2023 - cell.com
The HIV-1 protease is one of several common key targets of combination drug therapies for
human immunodeficiency virus infection and acquired immunodeficiency syndrome. During …

ATOMDANCE: Kernel-based denoising and choreographic analysis for protein dynamic comparison

GA Babbitt, M Rajendran, ML Lynch… - Biophysical …, 2024 - cell.com
Comparative methods in molecular evolution and structural biology rely heavily upon the
site-wise analysis of DNA sequence and protein structure, both static forms of information …

ATOMDANCE: machine learning denoising and resonance analysis for functional and evolutionary comparisons of protein dynamics

GA Babbitt, M Rajendran, ML Lynch, R Asare-Bediako… - bioRxiv, 2023 - biorxiv.org
Comparative methods in molecular biology and molecular evolution rely exclusively upon
the analysis of DNA sequence and protein structure, both static forms of information …

Refining SARS-CoV-2 Intra-host Variation by Leveraging Large-Scale Sequencing Data

F Mostefai, JC Grenier, R Poujol, J Hussin - bioRxiv, 2024 - biorxiv.org
Understanding the evolution of viral genomes is essential for elucidating how viruses adapt
and change over time. Analyzing intra-host single nucleotide variants (iSNVs) provides key …

2 Molecular Biology of SARS-CoV-2

R Patarca, WA Haseltine - The COVID-19 Textbook: Science …, 2023 - books.google.com
2 Molecular Biology of SARS-CoV-2 Page 85 CHAPTER 2 Molecular Biology of SARS-CoV-2
Roberto Patarca • William A. Haseltine Introduction Taxonomy, Zoonotic Origin, and Evolution …

Evolution of drug resistance drives progressive destabilizations in functionally conserved molecular dynamics of the flap region of the HIV-1 protease

M Rajendran, MC Ferran, L Mouli, E Everingham… - bioRxiv, 2022 - biorxiv.org
The HIV-1 protease is one of several common key targets of combination drug therapies for
human immunodeficiency virus infection and acquired immunodeficiency syndrome …

Disentangling Human Nature: Environment, Evolution and Our Existential Predicament

LGA Espinoza - Nature Anthropology, 2024 - hal.science
Throughout our entire evolutionary history, the physical environment has played a significant
role in shaping humans' subsistence adaptations. As early humans began to colonise novel …

Other Mutants

J Zhang - Optimization-based Molecular Dynamics Studies of …, 2023 - Springer
This chapter studies all the variants of the SAR-CoV-2 RBD wild-type: alpha-variant
(N501Y), alpha1-variant (N501Y, P681H, 69–70del), alpha2-variant (N501Y, P681H, 69 …