Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

Mammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric
repeat–binding factors TRF1 and TRF2. Inhibition of TRF2 results in immediate deprotection …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Telomeres protect chromosome ends through the interaction of telomeric repeats with
shelterin, a protein complex that represses DNA damage signaling and DNA repair …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …