Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Image-based screening is used to measure a variety of phenotypes in cells and whole
organisms. Combined with perturbations such as RNA interference, small molecules, and …

Small interfering RNAs (siRNAs) are widely used to study gene function owing to the ease
with which they silence target genes, and there is considerable interest in their potential for …

Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …

Endocytosis is a complex process fulfilling many cellular and developmental functions.
Understanding how it is regulated and integrated with other cellular processes requires a …

Collisions between the DNA replication machinery and co-transcriptional R-loops can
impede DNA synthesis and are a major source of genomic instability in cancer cells. How …

Post‐transcriptional regulation by microRNAs and siRNAs depends not only on
characteristics of individual binding sites in target mRNA molecules, but also on system …

Proper regulation of chromatin structure is necessary for the maintenance of cell type-
specific gene expression patterns. The embryonic stem cell (ESC) expression pattern …

Short interfering RNAs (siRNAs) are widely used as tool for gene inactivation in basic
research and therapeutic applications. One of the major shortcomings of siRNA experiments …

The spliceosome, a dynamic assembly of proteins and RNAs, catalyzes the excision of
intron sequences from nascent mRNAs. Recent work has suggested that the activity and …